Intragenic ATM Methylation in Peripheral Blood DNA as a Biomarker of Breast Cancer Risk
Identifieur interne : 005B27 ( Main/Exploration ); précédent : 005B26; suivant : 005B28Intragenic ATM Methylation in Peripheral Blood DNA as a Biomarker of Breast Cancer Risk
Auteurs : Kevin Brennan [Royaume-Uni] ; Montserrat Garcia-Closas [Royaume-Uni] ; Nick Orr [Royaume-Uni] ; Olivia Fletcher [Royaume-Uni] ; Michael Jones [Royaume-Uni] ; Alan Ashworth [Royaume-Uni] ; Anthony Swerdlow [Royaume-Uni] ; Kconfab Investigators [Australie] ; Elid Riboli [Royaume-Uni] ; Paolo Vineis [Royaume-Uni, Italie] ; Miren Dorronsoro [Espagne] ; Francoise Clavel-Chapelon [France] ; Salvatore Panico [Italie] ; N. Charlotte Onland-Moret [Pays-Bas] ; Dimitrios Trichopoulos [États-Unis, Grèce] ; Rudolf Kaaks [Allemagne] ; Kay-Tee Khaw [Royaume-Uni] ; Robert Brown [Royaume-Uni] ; James M. Flanagan [Royaume-Uni]Source :
- Cancer research : (Baltimore) [ 0008-5472 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Few studies have evaluated the association between DNA methylation in white blood cells (WBC) and the risk of breast cancer. The evaluation of WBC DNA methylation as a biomarker of cancer risk is of particular importance as peripheral blood is often available in prospective cohorts and easier to obtain than tumor or normal tissues. Here, we used prediagnostic blood samples from three studies to analyze WBC DNA methylation of two ATM intragenic loci (ATMmvp2a and ATMmvp2b) and genome-wide DNA methylation in long interspersed nuclear element-1 (LINE1) repetitive elements. Samples were from a case-control study derived from a cohort of high-risk breast cancer families (KConFab) and nested case-control studies in two prospective cohorts: Breakthrough Generations Study (BGS) and European Prospective Investigation into Cancer and Nutrition (EPIC). Bisulfite pyrosequencing was used to quantify methylation from 640 incident cases of invasive breast cancer and 741 controls. Quintile analyses for ATMmvp2a showed an increased risk of breast cancer limited to women in the highest quintile [OR, 1.89; 95% confidence interval (CI), 1.36-2.64; P = 1.64 × 10-4]. We found no significant differences in estimates across studies or in analyses stratified by family history or menopausal status. However, a more consistent association was observed in younger than in older women and individually significant in KConFab and BGS, but not EPIC. We observed no differences in LINE1 or ATMmvp2b methylation between cases and controls. Together, our findings indicate that WBC DNA methylation levels at ATM could be a marker of breast cancer risk and further support the pursuit of epigenome-wide association studies of peripheral blood DNA methylation.
Affiliations:
- Allemagne, Australie, Espagne, France, Grèce, Italie, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Angleterre de l'Est, Attique (région), Bade-Wurtemberg, District de Karlsruhe, Grand Londres, Massachusetts, Piémont, Utrecht (province), Île-de-France
- Athènes, Cambridge, Heidelberg, Londres, Paris, Turin, Utrecht
- Université de Cambridge
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aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Peter MacCallum Cancer Center</wicri:noRegion></affiliation></author><author><name sortKey="Riboli, Elid" sort="Riboli, Elid" uniqKey="Riboli E" first="Elid" last="Riboli">Elid Riboli</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Public Health, Imperial College</s1><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>School of Public Health, Imperial College</wicri:noRegion></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MRC-HPACentre, Imperial College</s1><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>MRC-HPACentre, Imperial College</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>HuGeF Foundation</s1><s2>Torino</s2><s3>ITA</s3><sZ>10 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Charlotte Onland-Moret</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</s1><s2>Utrecht</s2><s3>NLD</s3><sZ>14 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name><affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Department of Epidemiology, Harvard School of Public Health</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Hellenic Health Foundation</s1><s2>Athens</s2><s3>GRC</s3><sZ>15 aut.</sZ></inist:fA14><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Division of Cancer Epidemiology, German Cancer Research Center</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="4"><inist:fA14 i1="16"><s1>Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>17 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Brown, Robert" sort="Brown, Robert" uniqKey="Brown R" first="Robert" last="Brown">Robert Brown</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Epigenetics Unit, Department of Surgery and Cancer, Imperial College</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Epigenetics Unit, Department of Surgery and Cancer, Imperial College</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Section of Medicine, Institute for Cancer Research</s1><s2>London</s2><s3>GBR</s3><sZ>18 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Flanagan, James M" sort="Flanagan, James M" uniqKey="Flanagan J" first="James M." last="Flanagan">James M. 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wicri:level="1"><inist:fA14 i1="04"><s1>Breakthrough Breast Cancer Research Centre</s1><s3>GBR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Breakthrough Breast Cancer Research Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Genetics and Epidemiology, Institute of Cancer Research</s1><s2>Sutton</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Breakthrough Breast Cancer Research Centre</s1><s3>GBR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Breakthrough Breast Cancer Research Centre</wicri:noRegion></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Breakthrough Breast Cancer Research Centre</s1><s3>GBR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Breakthrough Breast Cancer Research Centre</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Genetics and Epidemiology, Institute of Cancer Research</s1><s2>Sutton</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Breakthrough Breast Cancer Research Centre</s1><s3>GBR</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Breakthrough Breast Cancer Research Centre</wicri:noRegion></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Genetics and Epidemiology, Institute of Cancer Research</s1><s2>Sutton</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Investigators, Kconfab" sort="Investigators, Kconfab" uniqKey="Investigators K" first="Kconfab" last="Investigators">Kconfab Investigators</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Peter MacCallum Cancer Center</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Peter MacCallum Cancer Center</wicri:noRegion></affiliation></author><author><name sortKey="Riboli, Elid" sort="Riboli, Elid" uniqKey="Riboli E" first="Elid" last="Riboli">Elid Riboli</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Public Health, Imperial College</s1><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>School of Public Health, Imperial College</wicri:noRegion></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MRC-HPACentre, Imperial College</s1><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>MRC-HPACentre, Imperial College</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>HuGeF Foundation</s1><s2>Torino</s2><s3>ITA</s3><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Public Health Division of Gipuzkoa, IIS Institute BioDonostia, Basque Health Department; CIBER Epidemiologia y Salud Pública, CIBERESP</s1><s2>Gipuzkoa</s2><s3>ESP</s3><sZ>11 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Gipuzkoa</wicri:noRegion></affiliation></author><author><name sortKey="Clavel Chapelon, Francoise" sort="Clavel Chapelon, Francoise" uniqKey="Clavel Chapelon F" first="Francoise" last="Clavel-Chapelon">Francoise Clavel-Chapelon</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>INSERM, Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy, University Paris-Sud</s1><s2>Paris</s2><s3>FRA</s3><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Clinical and Experimental Medicine, Federico II University</s1><s2>Naples</s2><s3>ITA</s3><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</s1><s2>Utrecht</s2><s3>NLD</s3><sZ>14 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name><affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Department of Epidemiology, Harvard School of Public Health</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Hellenic Health Foundation</s1><s2>Athens</s2><s3>GRC</s3><sZ>15 aut.</sZ></inist:fA14><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Division of Cancer Epidemiology, German Cancer Research Center</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="4"><inist:fA14 i1="16"><s1>Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>17 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Brown, Robert" sort="Brown, Robert" uniqKey="Brown R" first="Robert" last="Brown">Robert Brown</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Epigenetics Unit, Department of Surgery and Cancer, Imperial College</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Epigenetics Unit, Department of Surgery and Cancer, Imperial College</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Section of Medicine, Institute for Cancer Research</s1><s2>London</s2><s3>GBR</s3><sZ>18 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Flanagan, James M" sort="Flanagan, James M" uniqKey="Flanagan J" first="James M." last="Flanagan">James M. Flanagan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Epigenetics Unit, Department of Surgery and Cancer, Imperial College</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Epigenetics Unit, Department of Surgery and Cancer, Imperial College</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Cancer research : (Baltimore)</title><title level="j" type="abbreviated">Cancer res. : (Baltimore)</title><idno type="ISSN">0008-5472</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Cancer research : (Baltimore)</title><title level="j" type="abbreviated">Cancer res. : (Baltimore)</title><idno type="ISSN">0008-5472</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological fluid</term><term>Biological marker</term><term>Blood</term><term>Breast cancer</term><term>DNA</term><term>Methylation</term><term>Risk factor</term><term>Tumor suppressor gene</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Gène suppresseur tumeur</term><term>Méthylation</term><term>Liquide biologique</term><term>Sang</term><term>DNA</term><term>Marqueur biologique</term><term>Cancer du sein</term><term>Facteur risque</term><term>Gène ATM</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Few studies have evaluated the association between DNA methylation in white blood cells (WBC) and the risk of breast cancer. The evaluation of WBC DNA methylation as a biomarker of cancer risk is of particular importance as peripheral blood is often available in prospective cohorts and easier to obtain than tumor or normal tissues. Here, we used prediagnostic blood samples from three studies to analyze WBC DNA methylation of two ATM intragenic loci (ATMmvp2a and ATMmvp2b) and genome-wide DNA methylation in long interspersed nuclear element-1 (LINE1) repetitive elements. Samples were from a case-control study derived from a cohort of high-risk breast cancer families (KConFab) and nested case-control studies in two prospective cohorts: Breakthrough Generations Study (BGS) and European Prospective Investigation into Cancer and Nutrition (EPIC). Bisulfite pyrosequencing was used to quantify methylation from 640 incident cases of invasive breast cancer and 741 controls. Quintile analyses for ATMmvp2a showed an increased risk of breast cancer limited to women in the highest quintile [OR, 1.89; 95% confidence interval (CI), 1.36-2.64; P = 1.64 × 10<sup>-4</sup>]. We found no significant differences in estimates across studies or in analyses stratified by family history or menopausal status. However, a more consistent association was observed in younger than in older women and individually significant in KConFab and BGS, but not EPIC. We observed no differences in LINE1 or ATMmvp2b methylation between cases and controls. Together, our findings indicate that WBC DNA methylation levels at ATM could be a marker of breast cancer risk and further support the pursuit of epigenome-wide association studies of peripheral blood DNA methylation.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Attique (région)</li><li>Bade-Wurtemberg</li><li>District de Karlsruhe</li><li>Grand Londres</li><li>Massachusetts</li><li>Piémont</li><li>Utrecht (province)</li><li>Île-de-France</li></region><settlement><li>Athènes</li><li>Cambridge</li><li>Heidelberg</li><li>Londres</li><li>Paris</li><li>Turin</li><li>Utrecht</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Brennan, Kevin" sort="Brennan, Kevin" uniqKey="Brennan K" first="Kevin" last="Brennan">Kevin Brennan</name></noRegion><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><name sortKey="Brown, Robert" sort="Brown, Robert" uniqKey="Brown R" first="Robert" last="Brown">Robert Brown</name><name sortKey="Brown, Robert" sort="Brown, Robert" uniqKey="Brown R" first="Robert" last="Brown">Robert Brown</name><name sortKey="Flanagan, James M" sort="Flanagan, James M" uniqKey="Flanagan J" first="James M." last="Flanagan">James M. Flanagan</name><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><name sortKey="Riboli, Elid" sort="Riboli, Elid" uniqKey="Riboli E" first="Elid" last="Riboli">Elid Riboli</name><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name></country><country name="Australie"><noRegion><name sortKey="Investigators, Kconfab" sort="Investigators, Kconfab" uniqKey="Investigators K" first="Kconfab" last="Investigators">Kconfab Investigators</name></noRegion></country><country name="Italie"><region name="Piémont"><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name></region><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name></country><country name="Espagne"><noRegion><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Clavel Chapelon, Francoise" sort="Clavel Chapelon, Francoise" uniqKey="Clavel Chapelon F" first="Francoise" last="Clavel-Chapelon">Francoise Clavel-Chapelon</name></region></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name></region></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name></region></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name></region></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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